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This is consistent with the hypothesis that type 1 diabetes is an autoimmune disease and that autoantibody production is an early step in the development of type 1 diabetes.

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In addition, the establishment of the LADA diagnosis may be useful in selecting therapy (Brophy et al, 2007) Antibodies to GAD are often markedly elevated in patients with the stiff-person syndrome (also referred to as stiff-man syndrome), a condition that is associated with fluctuating stiffness and paroxysmal spasms of the trunk and legs.

Note: For Trina Health artificial pancreas treatment, see CPB 0742 - Intermittent Intravenous Insulin Therapy.